趙春杰	教授、博士生導(dǎo)師 東南大學(xué)醫(yī)學(xué)院 副院長(zhǎng)
	電話：	025-83272340
	E-mail：	[email protected]
	Labweb：
	辦公地點(diǎn)：

個(gè)人簡(jiǎn)介：
畢業(yè)于南京大學(xué)生物學(xué)系，獲理學(xué)學(xué)士和碩士學(xué)位，1994年赴日本留學(xué)，2000年獲日本東京大學(xué)醫(yī)學(xué)系研究科分子細(xì)胞生物學(xué)博士學(xué)位，同年為日本學(xué)術(shù)振興會(huì)外國(guó)人特別研究員，2001年起，在美國(guó)加州大學(xué)舊金山分校(UCSF)作博士后，2004年8月起受聘為東南大學(xué)教授。主要研究神經(jīng)系統(tǒng)發(fā)育缺陷而致相關(guān)神經(jīng)精神疾病的發(fā)生機(jī)制。曾獲國(guó)家杰出青年科學(xué)基金資助，作為首席科學(xué)家和首席專(zhuān)家主持國(guó)家重點(diǎn)基礎(chǔ)研究計(jì)劃（973）以及863項(xiàng)目。研究工作同時(shí)受到國(guó)家自然科學(xué)基金面上及重點(diǎn)項(xiàng)目支持。曾入選首批江蘇省“333工程”中青年科技領(lǐng)軍人才，江蘇省特聘教授；獲江蘇省有突出貢獻(xiàn)中青年專(zhuān)家稱(chēng)號(hào)；2009年入選“新世紀(jì)百千萬(wàn)人才工程”國(guó)家級(jí)人選；享受?chē)?guó)務(wù)院特殊津貼?，F(xiàn)任中國(guó)神經(jīng)科學(xué)學(xué)會(huì)理事、江蘇省發(fā)育生物學(xué)會(huì)副理事長(zhǎng)、江蘇省解剖學(xué)會(huì)副理事長(zhǎng)等。

研究方向：端腦發(fā)育的調(diào)控與相關(guān)神經(jīng)精神疾病的病理機(jī)制

海馬、新皮層是行使腦高級(jí)功能如學(xué)習(xí)記憶、情感的重要功能區(qū)域，多種認(rèn)知和情感障礙均與早期海馬以及新皮層神經(jīng)環(huán)路的發(fā)育異常密切相關(guān)，但其發(fā)生發(fā)展機(jī)制尚不明了。本課題組主要利用基因工程小鼠，通過(guò)基因敲除、轉(zhuǎn)基因等手段揭示海馬和新皮層神經(jīng)環(huán)路發(fā)育過(guò)程中神經(jīng)干細(xì)胞的分化、神經(jīng)元遷移和成熟的調(diào)控機(jī)制，探討環(huán)路中興奮性神經(jīng)元與抑制性中間神經(jīng)元二者之間的平衡維持機(jī)制，旨在為深入理解腦高級(jí)功能的神經(jīng)生物學(xué)基礎(chǔ)及其相關(guān)疾病的發(fā)生機(jī)制提供線索。

本課題組日常負(fù)責(zé)人聯(lián)系方式：

劉琍： 025-83272362

發(fā)表論文：

1.Yang Y Shen W, Ni Y,Su Y, Yang Z, ZhaoC*. Impaired interneuron development after Foxg1 disruption. Cerebral cortex. In press.

2.Liu R, Yang Y, Shen J, Chen H, Zhang Q, Ba R, Wei Y, Li KC, Zhang X, ZhaoC*. Fstl1 is involved in the regulation of radial glial scaffold development.Molecular Brain.2015 Sep 17;8(1):53. doi: 10.1186/s13041-015-0144-8.

3.Liu J, Liu B, Zhang X, Yu B, Guan W, Wang K, Yang Y, Gong Y, Wu X, Yanagawa Y, Wu S, Zhao C*. Calretinin-positive L5a pyramidal neurons in the development of the paralemniscal pathway in the barrel cortex. Molecular Brain. 2014, Nov 18, 7 (1) :84 , doi:10.1186/s13041-014-0084-8.

4.Wu X, Gu X, Han X, Du A, Jiang Y, Zhang X, Wang Y, Cao G, Zhao C*. A Novel Function for FoxM1 in Interkinetic Nuclear Migration in the Developing Telencephalon And Anxiety-related Behavior. The Journal of Neuroscience. 2014 Jan; 34(4):1510-1522.

5.Huang Y, Song NN, Lan W, Zhang Q, Zhang L, Zhang L, Hu L, Chen JY, Zhao C, Li L, Xu L, Ding YQ*. Sensory input is required for callosal axon targeting in the somatosensory cortex. Mol Brain. 2013 Dec 5;6(1):53.doi: 10.1186/1756-6606-6-53.

6.Nie B, Chen K, Zhao S, Liu J, Gu X, Yao Q, Hui J, Zhang Z, Teng G, Zhao C, Shan B^* . A Rat Brain MRI Template with Digital Stereotaxic Atlas of Fine Anatomical Delineations in Paxinos Space and its Automated Application in Voxel-Wise Analysis. Human Brain Mapping.2013 Jun;34(6):1306-18.

7.Tian C, Gong Y, Yang Y, Shen W, Wang K, Liu J, Xu B, Zhao J, Zhao C^*. Foxg1 Has An essential Role in Postnatal Development of The Dentate gyrus. The Journal of Neuroscience. 2012. Feb., 32(9):2931-2949.

8.Gu X, Liu B, Wu X, Yan Y, Zhang Y, Wei Y,. Pleasure SJ, Zhao C^*. Inducible Genetic Lineage Tracing of Cortical Hem Derived Cajal-Retzius Cells Reveals Novel Properties. PLoS ONE. 2011;6(12):e28653.

9.Li Y, Tian C, Yang Y, Yan Y, Ni Y, Wei Y, Pleasure SJ, Zhao C^*. An inducible transgenic Cre mouse line for the study of hippocampal development and adult neurogenesis. Genesis. 2011 Dec. 49 (12):919-926.

10.Zhou W, Zhang Y, Li Y, Wei YS, Liu G, Liu DP, Pleasure SJ, Xie W, Zhao C^*. A transgenic Cre mouse line for the study of cortical and hippocampal development.Genesis.2010 May; 48(5):343-50.

11.Yang Y, Liu J, Mao H, Hu YA, Yan Y, Zhao C^*. The expression pattern of Follistatin-like 1 in mouse central nervous system development.. Gene Expr Patterns. 2009 Oct; 9(7):532-540.

12.Gu X, Yan Y, Li H, He D, Pleasure SJ, Zhao C^*.Characterization of the Frizzled10-CreER^TM Transgenic Mouse: An Inducible Cre Line for the Study of Cajal–Retzius Cell Development. Genesis. 2009 Mar; 47(3): 210 – 216.

13.Yan Y, Li Y, Hu C, Gu X, Liu J, Hu YA, Yang Y, Wei Y, Zhao C^*. Expression of Frizzled10 in mouse nervous system. Gene Expr Patterns. 2009 Mar; 9 (3):173-177.

14.Hu C, Liu J, Zhang Y, Li Y, Xie W, Zhao C^*. A useful transgenic mouse line for studying the development of spinal nociceptive circuits.Neuroscience lett. 2009 Jan 30; 450 (2):211-216.

15.Gu X, He D, Li Y, Hu C, Wei YS, Liu G, Liu D, Pleasure SJ, Xie W, Zhao C^*. Generation of Frizzled10-Cre Transgenic Mouse Line: A Useful Tool for the Study of Dorsal Telencephalic Development. Genesis. 2008 Oct; 46 (10):523-9.

16.Hu YA, Gu X, Liu J, Yang Y, Yan Y, Zhao C^*. Expression pattern of wnt inhibitor factor 1(wif1) during the development in mouse CNS. Gene Expr Patterns. 2008 Sep; 8 (7-8): 515-522.

17.Zhao C, Guan W, Pleasure SJ. A Transgenic Marker Mouse Line Labels Cajal-Retzius Cells from the Cortical Hem and Thalamocortical axons.Brain Res. 2006 Mar 10; 1077 (1):48-53. (cover story)

18.Zhao C^*, Avilés C, Abel RA, Almli CR, McQuillen P, Pleasure SJ*. Hippocampal and Visuospatial Learning Defects in Mice with Deletion of Frizzled9, a Gene in the Williams Syndrome Deletion Interval.Development.2005 Jun; 132(12):2917-2927.

19.Zhao C^*, Pleasure SJ*.Frizzled9 Protein Is Regionally Expressed in the Developing Medial Wall of the Cortex and the Cells Derived from This Region.Developmental Brain Research. 2005 Jun 9; 157 (1):93-97.

20.Zhao C, Pleasure SJ.The Frizzled9 Promoter Drives Expression of Transgenes in the Medial Wall of the Cortex and Its Chief Derivative the Hippocampus. Genesis.2004 Sep; 40(1):32-9.

21.Zhou CJ, Zhao C, Pleasure SJ.Wnt Signaling Mutants Have Decreased Dentate Granule Cell Production And Radial Glial Scaffold Abnormalities. The Journal of Neuroscience.  2004 Jan 7;24(1):121-126.

22.Zhao C,Takita J, Tanaka Y, Setou M, Nakagawa T, Takeda S, Yang HW, Terada S, Nakata T, Takei Y, Saito M, Tsuji S, Hayashi Y, Hirokawa N.Charcot-Marie-Tooth Disease Type 2A Caused by Mutation in a Microtubule Motor KIF1B.Cell. 2001 Jun 1;105(5):587-597.