謝 維	教授、博士生導(dǎo)師 “發(fā)育與疾病相關(guān)基因”教育部重點(diǎn)實(shí)驗(yàn)室 主任
	電話：	025-83790970
	E-mail：	[email protected]
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	辦公地點(diǎn)：	南京市四牌樓2號(hào)，李文正樓北221

個(gè)人簡介：

   1981年7月參加工作，1991年6月畢業(yè)于南京鐵道醫(yī)學(xué)院微生物學(xué)與免疫學(xué)專業(yè)，獲碩士學(xué)位；1995年10月畢業(yè)于南京大學(xué)生物化學(xué)與分子生物學(xué)系，獲博士學(xué)位。1997年1月至1998年12月在美國羅切斯特大學(xué)醫(yī)學(xué)中心作博士后；1999年5月至2001年8月在加拿大多倫多大學(xué)附屬多倫多病童醫(yī)院博士后、訪問學(xué)者。2001年9月作為教育部“CJ學(xué)者獎(jiǎng)勵(lì)計(jì)劃”特聘教授，受聘為東南大學(xué)基礎(chǔ)醫(yī)學(xué)院遺傳學(xué)研究中心主任，博士生導(dǎo)師；2003年獲準(zhǔn)建設(shè)“發(fā)育與疾病相關(guān)基因”教育部重點(diǎn)實(shí)驗(yàn)室，任主任；2004年4月至2009年11月任東南大學(xué)基礎(chǔ)醫(yī)學(xué)院院長，2009年12月至2019年12月，任東南大學(xué)生命科學(xué)研究院院長。先后獲得國家自然科學(xué)基金（面上、重點(diǎn)）、國家杰出青年科學(xué)基金、美國NIH基金（RO3）、國家“973”重大基礎(chǔ)研究項(xiàng)目等資助。

研究方向：突觸發(fā)育調(diào)控與認(rèn)知疾病機(jī)制

   大腦通過約10¹⁵個(gè)突觸連接而成的巨大通訊網(wǎng)絡(luò)來進(jìn)行信息處理、行使功能。突觸通過自身的可塑性，傳遞、轉(zhuǎn)變和完善信號(hào)。突觸細(xì)胞粘附因子，通過連接突觸前、后細(xì)胞，調(diào)節(jié)突觸傳遞信號(hào)，并且通過形成特異性的突觸功能來決定神經(jīng)網(wǎng)絡(luò)的特性。家系分析發(fā)現(xiàn)，人類突觸細(xì)胞粘附因子基因發(fā)生突變與孤獨(dú)癥、精神分裂癥等關(guān)聯(lián)；基因組水平研究顯示，包括孤獨(dú)癥、精神分裂癥等多種認(rèn)知性疾病，均存在編碼突觸分子，如Caherins、Protocadherins、L1CAM、Neuroligin、Neurexin、CNTNAP2和Contactins等的基因異常，但其致病機(jī)制不清。本研究組以神經(jīng)元表面蛋白分子為研究對象，應(yīng)用綜合研究手段，結(jié)合模式生物，探索突觸發(fā)生、成熟、環(huán)路形成以及在學(xué)習(xí)記憶等高級(jí)神經(jīng)活動(dòng)與行為中的作用，探討其在遺傳和表觀遺傳水平上的調(diào)控機(jī)制，為闡明其在相關(guān)的認(rèn)知障礙與疾病中的作用奠定基礎(chǔ)。

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呂卉卉：025-83790976 

近期代表性論文：

1.  Moyi Li*, Yan Zhuang, Ranjan Batra, James D. Thomas, Mao Li, Curtis A Nutter, Marina M. Scotti, Helmut A Carter, Zhan Jun Wang, Xu Sheng Huang, Chuan Qiang Pu, Maurice S. Swanson, Wei Xie *. HNRNPA1-induced spliceopathy in a transgenic mouse model of myotonic dystrophy. Proceedings of the National Academy of Sciences of the United States of America, 2020,117(10): 5472-5477.

2.  Xuechen Zhou, Rui Hao, Chen Chen, Zhipeng Su, Linhong Zhao, Zhuojuan Luo, Wei Xie *. Rapid Delivery of Nanobodies/VHHs into Living Cells via Expressing In Vitro-Transcribed mRNA. Molecular Therapy - Methods & Clinical Development, 2020, 17:401-408.

3.  Rui Mao, Rui Deng, Yan Wei, Lifang Han, Yanghong Meng, Wei Xie*, Zhengping Jia*. LIMK1 and LIMK2 regulate cortical development through affecting neural progenitor cell proliferation and migration. Mol Brain, 2019, 12(1):67.

4. Guanglin Xing, Moyi Li, Menglong Rui, Nana Tao, Yan Zhuang, Huihui Lv, Junhai Han, Zhengping Jia*, and Wei Xie*. Neuroligin 1 Regulates Postsynaptic Actin Cytoskeleton via WAVE Regulatory Complex in Drosophila Neuromuscular Junction, eLife, 2018, 7:e30457.

5. Jun Wu, Yao Tian, Guanglin Xing, Nana Tao, Huihui Lv, Junhai Han, Chengqi Lin and Wei Xie*. Proteolytic Maturation of Drosophila Neuroligin 3 by Tumor Necrosis Factor α-converting Enzyme in the Nervous System. Biochimica et Biophysica Acta(BBA) - General Subjects, 2018, 1862(3):440-450

6. Xinwang Zhang, Menglong Rui, Guangming Gan, Cong Huang, Jukang Yi, Huihui Lv, Junhai Han, and Wei Xie*. Presynaptic Neuroligin 4 Positively Regulate Neuromuscular Synaptic Growth in Drosophila via BMP Signaling Pathway. The Journal of Biological Chemistry, 2017, 292(44):17991-18005.

7. Menglong Rui, Jinjun Qian, Lijuan Liu, Yihan Cai, Huihui Lv, Junhai Han, Zhengping Jia, Wei Xie*. The neuronal protein neurexin directly interacts with the Scribble-Pix complex to stimulate F-actin assembly for presynaptic vesicle clustering. The Journal of Biological Chemistry, 2017, 292(35):14334-14348

8. Renjun Tu, Jinjun Qian, Menglong Rui, Nana Tao, Mingkuan Sun, Yan Zhuang, Huihui Lv, Junhai Han, Moyi Li, Wei Xie*. Proteolytic cleavage is required for Neuroligin 2 maturation and function in Drosophila. Journal of Molecular Cell Biology, 2017, 9(3):231-242

9. An Liu, Zikai Zhou, Rui Dang, Guiqing He, Celeste Leung, Daniel Pak, Zhengping Jia*, Wei Xie*. Neuroligin-1 regulates spines and synaptic plasticity via LIMK1/cofilin mediated actin reorganization. The Journal of Cell Biology, 2016, 212(4):449-463 (Cover Story, COMMENT:Karen A. NewellLitwa. Breaking down to build up: Neuroligin’s C-terminal domain strengthens the synapse. J. Cell Biol. 212, 375-377)

10. Shuting Xia, Zikai Zhou, Celeste Leung, Yuehua Zhu, Xingxiu Pan, Maria Morena, Matthew N. Hill*, Wei Xie*, Zhengping Jia*. p21-Activated Kinase 1 Restricts Tonic Endocannabinoid Signaling in the Hippocampus. eLife, 2016, 5:e14653.

11. Xingxiu Pan, Xinxia Chang, Celeste Leung, Zikai Zhou, Feng Cao, Wei Xie*, Zhengping Jia*. PAK1 regulates cortical development via promoting neuronal migration and progenitor cell proliferation. Molecular Brain, 2015, 8:36

12. Guanglin Xing, Guangming Gan, Dandan Chen, Mingkuan Sun, Jukang Yi, Huihui Lv, Junhai Han, Wei Xie*. Drosophila Neuroligin3 Regulates Neuromuscular Junction Development and Synaptic Differentiation. The Journal of Biological Chemistry, 2014, 289(46):31867-31877 (Papers of the Week)

13. Yi Li, Zikai Zhou, Xinwang Zhang, Huawei Tong, Peipei Li, Zichao Zhang, Zhengping Jia, Wei Xie* and Junhai Han*. Drosophila Neuroligin4 regulates sleep through modulating GABA transmission. The Journal of Neuroscience, 2013, 33(39):15545-15554

14. Yao Tian, Yi Li, Mingkuan Sun, Wen Hu, Didi Wan, Jing Li, Junhai Han* and Wei Xie*. Neurexin Regulates Visual Function via Mediating Retinoid Transport to Promote Rhodopsin Maturation. Neuron, 2013, 77(2):311-322.

15. Mingkuan Sun, Guanglin Xing, Liudi Yuan, Guangming Gan, David Knight, Sheila Irene With, Cui He, Junhai Han, Xiankun Zeng, Ming Fang, Gabrielle L. Boulianne*, Wei Xie*. Neuroligin2 Is Required for Synapse Development and Function at the Drosophila Neuromuscular Junction. The Journal of Neuroscience, 2011, 31(2):687-699 (This Week in The Journal)