王蘇 教授，博士生導(dǎo)師

電話： 025-83790967

E-mail: [email protected]

辦公地點(diǎn)： 南京市四牌樓2號，李文正樓北樓217室

個(gè)人簡介

2010于北京大學(xué)獲得學(xué)士學(xué)位，2015于美國堪薩斯大學(xué)醫(yī)學(xué)中心獲得博士學(xué)位，并在美國Stowers醫(yī)學(xué)研究所擔(dān)任博士生研究員。2017年加入東南大學(xué)生命科學(xué)研究院擔(dān)任研究員，分別入選中組部海外高層次人才“青年項(xiàng)目”，江蘇省特聘教授，江蘇省雙創(chuàng)人才，江蘇省“六大人才高峰”高層次人才。

研究方向：神經(jīng)干細(xì)胞功能和中樞神經(jīng)系統(tǒng)發(fā)育調(diào)控機(jī)制

神經(jīng)干細(xì)胞因其自我更新及分化的潛力，成為未來臨床治療多種神經(jīng)退行性疾病的重要潛在治療方法。如何在活體中精確安全地調(diào)控神經(jīng)干細(xì)胞的命運(yùn)決定是當(dāng)今的主要研究熱點(diǎn)之一，也是制約其臨床應(yīng)用的主要瓶頸之一。本課題組通過多種模式生物，研究內(nèi)部命運(yùn)決定因子和外部微環(huán)境對神經(jīng)干細(xì)胞功能和中樞神經(jīng)系統(tǒng)發(fā)育的調(diào)控機(jī)制。

代表文獻(xiàn)：

1. Mengzhu Ou^#, Su Wang^#, Mingkuan Sun, Jinsong An, Huihui Lv, Xiankun Zeng, Steven X. Hou*, Wei Xie*.: The PDZ-GEF Gef26 regulates synapse development and function via FasII and Rap1 at the Drosophila neuromuscular junction. Experimental Cell Research. 2019 Jan 15; 374(2):342-352. doi: 10.1016/j.yexcr.2018.12.008.

2. Tingting Gao^#, Xin Zhao^#, Chenchen Liu^#, Binbin Shao^#, Xi Zhang, Kai Li, Jinyang Cai, Su Wang*, Xiaoyan Huang*.: Somatic Angiotensin I-Converting Enzyme Regulates Self-Renewal of Mouse Spermatogonial Stem Cells Through the Mitogen-Activated Protein Kinase Signaling Pathway. Stem Cells and Development. 2018 Aug 1;27(15):1021-1032. doi: 10.1089/scd.2017.0287.

3. Xing Ma^#, Xiujuan Zhu, Yingying Han, Benjamin Story, Trieu Do, Xiaoqing Song, Su Wang, Ying Zhang, Marco Blanchette, Madelaine Gogol, Kate Hall, Allison Peak, Perera Anoja, Ting Xie*.: Aubergine Controls Germline Stem Cell Self-Renewal and Progeny Differentiation via Distinct Mechanisms. Developmental Cell. 2017 Apr 24; 41(2):157-169. e5. doi: 10.1016/j.devcel.2017.03.023.

4. Tinglin Lu^#, Su Wang^#, Yuan Gao, Ying Mao, Zhihao Yang, Luping Liu, Xiaoqing Song, Jianquan Ni, Ting Xie*.: COP9-Hedgehog axis regulates the function of the germline stem cell progeny differentiation niche in the Drosophila ovary. Development. 2015 Dec 15;142(24):4242-52.

5. Su Wang^#, Yuan Gao, Xiaoqing Song, Xing Ma, Xiujuan Zhu, Ying Mao, Zhihao Yang, Jianquan Ni, Hua Li, Kathryn E Malanowski, Perera Anoja, Jungeun Park, Jeff Haug, Ting Xie*.: Wnt Signaling-Mediated Redox Regulation Maintains the Germline Stem Cell Differentiation Niche. eLife. 2015 Oct 9; 4. doi: 10.7554/eLife.08174

6. Lei Pan^#, Su Wang^#, Tinglin Lu^#, Changjiang Weng, Xiaoqing Song, Joseph K. Park, Jin Sun, Zhi-HaoYang, JunjingYu, Hong Tang, Dennis M. McKearin, Daniel A. Chamovitz, Jianquan Ni，Ting Xie*.: Protein competition switches the function of COP9 from self-renewal to differentiation. Nature. 2014 Oct 9; 514(7521):233-6.

7. Xing Ma^#, Su Wang, Trieu Do, Xiaoqing Song, Mayu Inaba, Yoshiya Nishimoto, Lu-ping Liu,Yuan Gao, Ying Mao, Hui Li, William McDowell, Jungeun Park, Kate Malanowski, Allison Peak, Anoja Perera, Hua Li, Karin Gaudenz, Jeff Haug, Yukiko Yamashita, Haifan Lin, Jian-quan Ni, Ting Xie*.: Piwi is required in multiple cell types to control germline stem cell lineage development in the Drosophila ovary. PLoS One. 2014 Mar 21; 9(3):e90267.

8. Xiaoxi Wang^#, Lei Pan^#, Su Wang^#, Jian Zhou, William McDowell, Jungeun Park, Jeff Haug, Karen Staehling, Hong Tang, Ting Xie*.: Histone H3K9 trimethylase Eggless controls germline stem cell maintenance and differentiation. PLoS Genet. 2011 Dec 22; 7(12):e1002426.

9. Daniel Kirilly^#, Su Wang^#, Ting Xie*.: Self-maintained escort cells form a germline stem cell differentiation niche. Development. 2011 Dec; 138(23):5087-97.

10. Shuyi Chen^#, Su Wang, Ting Xie*.: Restricting self-renewal signals within the stem cell niche: multiple levels of control. Curr Opin Genet Dev. 2011 Dec; 21(6):684-9.