張子超  研究員 博士生導(dǎo)師

Email：[email protected]

辦公地點(diǎn)：東南大學(xué)江北校區(qū)匯川樓A411

個(gè)人簡(jiǎn)介

1998-2002年，南京大學(xué)，生物化學(xué)專業(yè)，學(xué)士

2002-2005年，南京大學(xué)，生物化學(xué)與分子生物學(xué)，碩士

2005-2011年，美國(guó)得克薩斯州大學(xué)西南醫(yī)學(xué)中心，細(xì)胞調(diào)控專業(yè)，博士

2011-2012年，美國(guó)得克薩斯州大學(xué)西南醫(yī)學(xué)中心，藥理系，博士后

2012-2022年，東南大學(xué)，生命科學(xué)研究院，副教授

2022年至今，東南大學(xué)生命科學(xué)與技術(shù)學(xué)院，研究員

研究方向

兒童智力發(fā)育遲緩和老年人群中的神經(jīng)退行性疾病是常見多發(fā)的神經(jīng)系統(tǒng)疾病，目前人們對(duì)其復(fù)雜的發(fā)病機(jī)理知之甚少，缺乏有效的治療手段，是生物醫(yī)學(xué)領(lǐng)域里未解的難題。對(duì)神經(jīng)發(fā)育，突觸形成和維持，神經(jīng)遞質(zhì)的傳遞和神經(jīng)環(huán)路形成過程中關(guān)鍵分子及分子事件的研究是解開難題的核心。我們主要運(yùn)用生物化學(xué)與分子生物學(xué)，細(xì)胞生物學(xué)，結(jié)構(gòu)生物學(xué)，生物信息學(xué)和遺傳學(xué)等方法與手段，通過對(duì)細(xì)胞內(nèi)蛋白質(zhì)的表達(dá)調(diào)控，蛋白質(zhì)之間的相互作用，蛋白質(zhì)和RNA等生物大分子在細(xì)胞內(nèi)的轉(zhuǎn)運(yùn)以及相應(yīng)細(xì)胞生理生化功能的研究，來揭示神經(jīng)發(fā)育與退化過程的分子機(jī)制，探討智力發(fā)育遲緩和神經(jīng)退行性性疾病的發(fā)病機(jī)理，尋找新的治療手段。

代表性論文

1.  Liu, X., Xie, H., Liu, W., Zuo, J., Li, S.，..., Zhang, Z.C.*et al. (2024). Dynamic regulation of alternative polyadenylation by PQBP1 during neurogenesis. Cell reports 43, 114525. 10.1016/j.celrep.2024.114525.

2. Zhang, Z., Wang, Y., Zhao, J., Han, S., Zhang, Z.C.*, and Tian, Y*. (2023). High-Throughput Small Molecule Drug Screening For Age-Related Sleep Disorders Using Drosophila melanogaster. J Vis Exp. 10.3791/65787.

3. Liu, W.#, Xie, H.#, Liu, X.#, Xu, S., Cheng, S., Wang, Z., Xie, T., Zhang, Z.C*., and Han, J*. (2023). PQBP1 regulates striatum development through balancing striatal progenitor proliferation and differentiation. Cell reports 42, 112277. 10.1016/j.celrep.2023.112277.

4. Cheng, S., Liu, X., Yuan, L., Wang, N., Zhang, Z.C.*, and Han, J*. (2023). The role of PQBP1 in neural development and function. Biochem Soc Trans 51, 363-372. 10.1042/bst20220920.

5. Lopez-Martín, S., Albert, J., Pe?a Vila-Belda, M.D.M., Liu, X., Zhang, Z.C., Han, J., Jiménez de Domingo, A., Fernández-Mayoralas, D.M., Fernández-Perrone, A.L., Calleja-Pérez, B., et al. (2022). A mild clinical and neuropsychological phenotype of Renpenning syndrome: A new case report with a maternally inherited PQBP1 missense mutation. Appl Neuropsychol Child 11, 921-927. 10.1080/21622965.2021.1970551.

6. Wang, J.F., Han, J.H., and Zhang, Z.C.* (2021). Behavioral analyses in mouse models of autism spectrum disorders. Yi Chuan 43, 501-519. 10.16288/j.yczz.20-391.

7. Shen, Y.#, Zhang, Z.C.#*, Cheng, S.#, Liu, A., Zuo, J., Xia, S., Liu, X., Liu, W., Jia, Z., Xie, W., and Han, J*. (2021). PQBP1 promotes translational elongation and regulates hippocampal mGluR-LTD by suppressing eEF2 phosphorylation. Mol Cell 81, 1425-1438.e1410. 10.1016/j.molcel.2021.01.032.

8. Shen, Y., Liu, W., Zuo, J., Han, J., and Zhang, Z.C.* (2021). Protocol for visualizing newly synthesized proteins in primary mouse hepatocytes. STAR Protoc 2, 100616. 10.1016/j.xpro.2021.100616.

9. Shen, Y., Han, J., and Zhang, Z.C.* (2021). Novel regulation of the eEF2K/eEF2 pathway: prospects of 'PQBP1 promotes translational elongation and regulates hippocampal mGluR-LTD by suppressing eEF2 phosphorylation'. J Mol Cell Biol 13, 392-394. 10.1093/jmcb/mjab017.

10. Jin, X., Tian, Y., Zhang, Z.C., Gu, P., Liu, C., and Han, J. (2021). A subset of DN1p neurons integrates thermosensory inputs to promote wakefulness via CNMa signaling. Curr Biol 31, 2075-2087.e2076. 10.1016/j.cub.2021.02.048.

11. Cheng, S., Shen, Y., Zhang, Z.C.*, and Han, J*. (2021). Protocol for interfering peptide injection into adult mouse hippocampus and spatial memory testing. STAR Protoc 2, 100679. 10.1016/j.xpro.2021.100679.

12. Zhang, Z.C., and Han, J*. (2020). The First National Prevalence of Autism Spectrum Disorder in China. Neurosci Bull 36, 959-960. 10.1007/s12264-020-00571-x.

13. Liu, X., Dou, L.X., Han, J., and Zhang, Z.C.* (2020). The Renpenning syndrome-associated protein PQBP1 facilitates the nuclear import of splicing factor TXNL4A through the karyopherin β2 receptor. The Journal of biological chemistry 295, 4093-4100. 10.1074/jbc.RA119.012214.

14. Gu, Q., Wu, J., Tian, Y., Cheng, S., Zhang, Z.C.*, and Han, J*. (2020). Gαq splice variants mediate phototransduction, rhodopsin synthesis, and retinal integrity in Drosophila. The Journal of biological chemistry 295, 5554-5563. 10.1074/jbc.RA120.012764.

15. Mu, Y., Tian, Y., Zhang, Z.C.*, and Han, J*. (2019). Metallophosphoesterase regulates light-induced rhodopsin endocytosis by promoting an association between arrestin and the adaptor protein AP2. The Journal of biological chemistry 294, 12892-12900. 10.1074/jbc.RA119.009602.

16. Guo, L., Kim, H.J., Wang, H., Monaghan, J., Freyermuth, F., Sung, J.C., O'Donovan, K., Fare, C.M., Diaz, Z., Singh, N., et al. (2018). Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains. Cell 173, 677-692.e620. 10.1016/j.cell.2018.03.002.

17. Zhang, X.Y., Qi, J., Shen, Y.Q., Liu, X., Liu, A., Zhou, Z., Han, J., and Zhang, Z.C.* (2017). Mutations of PQBP1 in Renpenning syndrome promote ubiquitin-mediated degradation of FMRP and cause synaptic dysfunction. Hum Mol Genet 26, 955-968. 10.1093/hmg/ddx010.

18. Tian, Y., Zhang, Z.C., and Han, J*. (2017). Drosophila Studies on Autism Spectrum Disorders. Neurosci Bull 33, 737-746. 10.1007/s12264-017-0166-6.

19. Li, Q., Li, Y., Wang, X., Qi, J., Jin, X., Tong, H., Zhou, Z., Zhang, Z.C., and Han, J*. (2017). Fbxl4 Serves as a Clock Output Molecule that Regulates Sleep through Promotion of Rhythmic Degradation of the GABA(A) Receptor. Curr Biol 27, 3616-3625.e3615. 10.1016/j.cub.2017.10.052.

20. Tong, H., Li, Q., Zhang, Z.C., Li, Y., and Han, J*. (2016). Neurexin regulates nighttime sleep by modulating synaptic transmission. Sci Rep 6, 38246. 10.1038/srep38246.

21. Wei, J.H.*, Zhang, Z.C., Wynn, R.M., and Seemann, J*. (2015). GM130 Regulates Golgi-Derived Spindle Assembly by Activating TPX2 and Capturing Microtubules. Cell 162, 287-299. 10.1016/j.cell.2015.06.014.

22. Wan, D.#, Zhang, Z.C.#, Zhang, X., Li, Q., and Han, J*. (2015). X chromosome-linked intellectual disability protein PQBP1 associates with and regulates the translation of specific mRNAs. Hum Mol Genet 24, 4599-4614. 10.1093/hmg/ddv191.

23. Tian, Y., Li, T., Sun, M., Wan, D., Li, Q., Li, P., Zhang, Z.C., Han, J.*, and Xie, W*. (2013). Neurexin regulates visual function via mediating retinoid transport to promote rhodopsin maturation. Neuron 77, 311-322. 10.1016/j.neuron.2012.11.012.

24. Li, Y., Zhou, Z., Zhang, X., Tong, H., Li, P., Zhang, Z.C., Jia, Z., Xie, W., and Han, J*. (2013). Drosophila neuroligin 4 regulates sleep through modulating GABA transmission. The Journal of neuroscience : the official journal of the Society for Neuroscience 33, 15545-15554. 10.1523/jneurosci.0819-13.2013.