方海同 副教授、碩士生導(dǎo)師
Email:: [email protected]
個(gè)人簡(jiǎn)介：
方海同，副教授，碩士生導(dǎo)師。主要研究方向：表觀遺傳學(xué)、細(xì)胞生物學(xué)。主要研究?jī)?nèi)容：1、細(xì)胞命運(yùn)決定中的表觀遺傳調(diào)控機(jī)制；2、表觀遺傳與疾病發(fā)生發(fā)展。在Cell、Nature Genetics、Nature Communications、PNAS等國(guó)際知名學(xué)術(shù)期刊發(fā)表論文10余篇。主持國(guó)家自然基金面上項(xiàng)目，江蘇省自然基金面上項(xiàng)目，國(guó)家重點(diǎn)研發(fā)項(xiàng)目核心骨干。
教育和工作簡(jiǎn)歷：
1998年至2002年 學(xué)士， 生物化學(xué)專業(yè)，安徽大學(xué)
2005年至2008年 碩士， 生物化學(xué)與分子生物學(xué)專業(yè)，中國(guó)科學(xué)技術(shù)大學(xué)
2008年至2012年 博士， 細(xì)胞生物學(xué)專業(yè)，中國(guó)科學(xué)院動(dòng)物研究所
2012年至2018年 博士后，新加坡分子與細(xì)胞生物學(xué)研究所
2018年11月至今 副教授， 東南大學(xué)生命科學(xué)與技術(shù)學(xué)院
發(fā)表論文：
1. Meng S*, Liu X*, Zhu S*, Xie P*, Fang H, Pan Q, Fang K, Li F, Zhang J, Che Z, Zhang Q, Mao G, Wang Y, Hu P, Chen K, Sun F, Xie W, Luo Z?, Lin C?. Young LINE-1 transposon 5’UTRs marked by elongation factor ELL3 function as enhancers to regulate na?ve pluripotency in embryonic stem cells. Nat Cell Biol. 2023 Sep;25(9):1319-1331.（封面文章）
2. Che Z*, Liu X*, Dai Q*, Fang K, Guo C, Yue J, Fang H, Xie P, Luo Z?, Lin C?. Distinct roles of the two SEC scaffold proteins, AFF1 and AFF4, in regulating RNA Pol II transcription elongation. J Mol Cell Biol. 2023 Aug 1:mjad049.
3. Fang H, Luo Z, Lin C. Epigenetic reorganization during early embryonic lineage specification. Genes Genomics. 2022 Mar;44(3):379-387.
4. Yue J, Dai Q, Hao S, Zhu S, Liu X, Tang Z, Li M, Fang H, Lin C?, Luo Z?. Suppression of the NTS-CPS1 regulatory axis by AFF1 in lung adenocarcinoma cells. J Biol Chem. 2021 Jan-Jun;296:100319.
5. Du H*, Chen C*, Wang Y, Yang Y, Che Z, Liu X, Meng S, Guo C, Xu M, Fang H, Wang F, Lin C?, Luo Z?. RNF219 interacts with CCR4-NOT in regulating stem cell differentiation. J Mol Cell Biol. 2020 Oct 26;12(11):894-905.
6. Fang H*, El Farran C*, Xing Q, Li P, Cheng H, Tushar W, Xu J, Zhang F, Li H, Lim B, Loh Y. Global H3.3 dynamics defines its bimodal role in cell fate transition. Nat Commun. 2018Apr 18;9:1537
7. Mzoughi S, Zhang J, Hequet D, Teo S, FangH, Xing Q, Bezzi M, Ong S, Shin M, Wollmann H, Wong E, Al-Haddawi M, Stewart C, Tergaonkar V, Dunn NR, Loh Y, Messerschmidt D and Guccione E. PRDM15 safeguards na?ve pluripotency by transcriptionally regulating WNT and MAPK/ERK signaling. Nat Genet. 2017 Sep;49(9):1354-1363.
8. Cheng H*, Ang Y*, El Farran C*, Li P*, Fang H, Liu T, Kong S, Chin L, Ling W, Lim K, Li H, Huber T , Loh M, Loh Y, Lim B. Reprogramming Mouse Fibroblasts into EngraftableMyeloerythroid and Lymphoid Progenitors: Induction and Underlying Mechanisms. Nat Commun. 2016 Nov 21;7:13396.
9. Yang B*, El Farran C*, Guo H*, Yu T*, Fang H, Wang H, Schlesinger S, Seah Y, Goh G, Neo S, Li Y, Lorincz M, Tergaonkar V, Lim T, Chen L, Gunaratne J, Collins J, Goff S, Daley G, Li H, Bard FA, Loh Y. Systematic identification of factors for provirus silencing in embryonic stem cells. Cell. 2015 Sep; 163(1): 230-245.
10. Fang H*, Zhang B*, Pan X, Gao L, Zhen T, Zhao H, Ma L, Xie J, Liu Z, Yu X, Cheng X, Feng T, Zhang F, Yang Y, Hu Z, Sheng G, Chen Y, Chen S, Chen Z, Zhou G. Bortezomib interferes with C-KIT processing and transforms the t(8;21)-generated fusion proteins into tumor- suppressing fragments in leukemia cells. Proc Natl Acad Sci U S A. 2012 Feb; 109(7): 2521-2526.
11. Zhou G, Hu Z, Fang H, Zhang F, Pan X, Chen X, Hu A, Xu L, Zhou G. Biologic activity of triptolide in t(8;21) acute myeloid leukemia cells. Leuk Res. 2011 Feb; 35(2): 214-218.
