張莎莎 副研究員 博士生導(dǎo)師
Email：[email protected]
辦公地點：生命健康高等研究院（東南大學科技產(chǎn)業(yè)園（棲霞區(qū)））
個人簡介：
2009年本科、2014年博士均畢業(yè)于清華大學生命科學學院，師從李蓬院士。2014年加入東南大學生命科學與技術(shù)學院，現(xiàn)任副研究員、博士生導(dǎo)師，兼任中大醫(yī)院耳鼻喉頭頸外科科研副主任、江蘇省發(fā)育生物學會聽覺專業(yè)委員會副主任委員、Sensory Neuroscience雜志青年編委等。先后入選江蘇省333高層次人才培養(yǎng)工程、江蘇省優(yōu)青、江蘇省科協(xié)青年科技人才托舉工程，先后主持多項國家自然科學基金等國家級和省部級科研項目。
研究方向：
1.利用內(nèi)耳干細胞再生功能性毛細胞，修復(fù)損傷的內(nèi)耳結(jié)構(gòu)、重建聽覺功能
2.內(nèi)耳靶向遞送載體的工程化構(gòu)建
近期代表性論文：(# co-first author; * corresponding author)
1. P. Jiang#, X. Ma#, S. Han#, L. Ma#, J. Ai, L. Wu, Y. Zhang, H. Xiao, M. Tian, W.. Tao*, S. Zhang*, and R. Chai*, Characterization of the microRNA transcriptomes and proteomics of cochlear tissue-derived small extracellular vesicles from mice of different ages after birth. Cellular and Molecular Life Sciences, 2022. 79(3): p. 154.2. S. Zhang#, Y. Zhang, L. Guo, Z. Zhang, Y. Dong, B. Shao, J. Qi, H. Zhou, W. Zhu, X. Yan, G. Hong, L. Zhang, X. Zhang, M. Tang, C. Zhao, X. Gao, R. Chai*. Knock-down of Foxg1 in Supporting Cells Increases the Transdifferentiation of Supporting Cells into Hair Cells in the Neonatal Mouse Cochlea. Cellular and Molecular Life Sciences, 77(7): 1401-1419, 2020
4. Y. Zhang#, S. Zhang#*, H. Zhou, X. Ma, L. Wu, M. Tian, S. Li, X. Qian*, X. Gao*, R. Chai*, Dync1li1 is required for the survival of mammalian cochlear hair cells by regulating the transportation of autophagosomes. PLOS Genetics, 2022. 18(6): p. e1010232.
5. Y. Chen#, R. Qiang#, Y. Zhang#, W. Cao#, L. Wu, P. Jiang, J. Ai, X. Ma, Y. Dong, X. Gao, H. Li*, L. Lu*, S. Zhang* and R. Chai*, The Expression and Roles of the Super Elongation Complex in Mouse Cochlear Lgr5+ Progenitor Cells. Frontiers in Cellular Neuroscience, 5: p. 735723, 2021.
6. J. Ai#, P. Jiang, J. Huang, H. Xiao, Y. Lin, M. Dai, Y. Wang, Y. Zhang, M. Tian, R. Chai, and S. Zhang*, The overexpression of Rps14 in Lgr5+ progenitor cells promotes hair cell regeneration in the postnatal mouse cochlea. Engineered Regeneration, 2023. 4(3): p. 328-336.
7. X. Ma#, S. Zhang#, S. Qin#, J. Guo, J. Yuan, R. Qiang, S. Zhou, W. Cao, J. Yang*, F. Ma*, R. Chai*. Transcriptomic and epigenomic analyses explore the potential role of H3K4me3 in neomycin-induced cochlear Lgr5+progenitor cell regeneration of hair cells. Human Cell. 2022. 35(4): p. 1030-1044.
