個人簡介：  

 1995年9月-1999年月     南京大學(xué)，生物化學(xué)專業(yè)，本科；

 1999年9月-2004年7月    南京大學(xué)，分子生物學(xué)與生物化學(xué)專業(yè)，碩博連讀；

 2004年7月-2008年8月    美國馬薩諸塞州大學(xué)醫(yī)學(xué)院，神經(jīng)生物學(xué)，博士后；

 2008年8月-2019年6月    東南大學(xué)，生命科學(xué)研究院，教授；

 2019年6月-現(xiàn)在         東南大學(xué)，生命科學(xué)與技術(shù)學(xué)院，教授。

研究方向：孤獨(dú)癥致病機(jī)制研究

     兒童孤獨(dú)癥譜系障礙是一種常見的神經(jīng)發(fā)育障礙性疾病，其發(fā)病率約1%。孤獨(dú)癥的核心臨床癥狀包括社會交往障礙和重復(fù)呆板的動作，不同的孤獨(dú)癥患者還伴隨如智力障礙、癲癇、睡眠障礙等臨床癥狀。目前人們對于兒童孤獨(dú)癥的致病機(jī)制尚不完全清楚。本實驗室以果蠅和小鼠為模式動物，運(yùn)用生物化學(xué)與分子生物學(xué)、細(xì)胞生物學(xué)、遺傳學(xué)、神經(jīng)生物學(xué)、電生理學(xué)及行為學(xué)解析孤獨(dú)癥關(guān)鍵致病基因的分子功能及孤獨(dú)癥的致病機(jī)制。

近期代表性論文：（* 通訊作者; # 第一作者）

1.   Liu J, Wang Y, Liu X, Han J*, Tian Y* (2024). Spatiotemporal changes in Netrin/Dscam1 signaling dictate axonal projection direction in Drosophila small ventral lateral clock neurons. Elife. 13:RP96041. doi: 10.7554/eLife.96041.

2.     Liu X, Xie H, Liu W, Zuo J, Li S, Tian Y, Zhao J, Bai M, Li J, Bao L, Han J*, Zhang ZC* (2024). Dynamic regulation of alternative polyadenylation by PQBP1 during neurogenesis. Cell Rep. 43:114525.

3.    Huang X, Cheng S*, Han J* (2024). Polyglutamine binding protein 1 regulates neurite outgrowth through recruiting N-WASP. J Biol Chem. 300(8):107537.

4.     Wang R, Sun H, Cao Y, Zhang Z, Chen Y, Wang X, Liu L, Wu J, Xu H, Wu D, Mu C, Hao Z, Qin S, Ren H*, Han J*, Fang M*, Wang G* (2024). Glucosylceramide accumulation in microglia triggers STING-dependent neuroinflammation and neurodegeneration in mice. Sci Signal. 17:eadk8249.

5.   Liu W^#, Xie H^#, Liu X^#, Xu S, Cheng S, Wang Z, Xie T, Zhang ZC*, Han J* (2023). PQBP1 regulates striatum development through balancing striatal progenitor proliferation and differentiation. Cell Rep. 42:112277.

6.    Jin X^#, Tian Y^#, Zhang ZC, Gu P, Liu C, Han J*(2021). A subset of DN1p neurons integrates thermosensory inputs to promote wakefulness via CNMa signaling. Curr Biol. 31:2075-2087.

7.    Shen Y^#, Zhang ZC^#,*, Cheng S^#, Liu A, Zuo J, Xia S, Liu X, Liu W, Jia Z, Xie W, Han J* (2021). PQBP1 promotes translational elongation and regulates hippocampal mGluR-LTD by suppressing eEF2 phosphorylation. Mol Cell, 81:1425-1438.

8.      Wu J, Ji X, Gu Q, Liao B, Dong W*, Han J* (2021). Parallel Synaptic Acetylcholine Signals Facilitate Large Monopolar Cell Repolarization and Modulate Visual Behavior in Drosophila. J Neurosci. 41:2164-2176.

9.     Gu Q^#, Wu J^#, Tian Y, Cheng S, Zhang ZC*, Han J* (2020). Gαq splice variants mediate phototransduction, rhodopsin synthesis, and retinal integrity in Drosophila. J Biol Chem. 295:5554-5563. (Cover Story).

10.   Mu Y, Tian Y, Zhang ZC*, Han J* (2019). Metallophosphoesterase regulates light-induced rhodopsin endocytosis by promoting an association between arrestin and the adaptor protein AP2. J Biol Chem. 294:12892-12900. (Cover Story).

11.   Li Q^#, Li Y^#, Wang X^#, Qi J, Jin X, Tong H, Zhou Z, Zhang ZC, Han J* (2017). Fbxl4 Serves as a Clock Output Molecule that Regulates Sleep through Promotion of Rhythmic Degradation of the GABAA Receptor. Curr Biol. 27:3616-3625.

12.   Liu L^#, Tian Y^#, Zhang XY, Zhang X, Li T, Xie W, Han J* (2017). Neurexin Restricts Axonal Branching in Columns by Promoting Ephrin Clustering. Dev Cell. 41:94-106. (Cover Story)

13.   Wang X, Mu Y, Sun M, Han J* (2017). Bidirectional regulation of fragile X mental retardation protein phosphorylation controls rhodopsin homoeostasis.J Mol Cell Biol. 9:104-116.

14. Wan D^#, Zhang ZC^#, Zhang X, Li Q, Han J* (2015). X chromosome-linked intellectual disability protein PQBP1 associates with and regulates the translation of specific mRNAs. Hum Mol Genet. 24:4599-614.

15.   Li T, Tan Y, Li Q, Chen H, Lv H, Xie W, Han J* (2015). The Neurexin-NSF interaction regulates short-term synaptic depression. J Biol Chem. 290:17656-67. (Cover Story).

16.   Hu W, Wang T, Wang X, and Han J* (2015). Ih Channels Control Feedback Regulation from Amacrine Cells to Photoreceptors. PLoS Biology. 13:e1002115.

17.   Li Y^#, Zhou Z^#, Zhang X, Tong H, Li P, Zhang ZC, Jia Z, Xie W*, Han J* (2013). Drosophila Neuroligin 4 Regulates Sleep through Modulating GABA Transmission.  J Neurosci. 33:15545-54.

18.  Tian Y, Li T, Sun M, Wan D, Li Q, Li P, Zhang Z, Han J*, Wei Xie* (2013). Neurexin Regulates Visual Function via Mediating Retinoid Transport to Promote Rhodopsin Maturation. Neuron 77: 311-322.

19.   Hu W, Wan D, Yu X, Cao J, Guo P, Li HS, Han J* (2012). Protein Gq modulates termination of phototransduction and prevents retinal degeneration. J Biol Chem 287:13911-8.

20.   Cao J^#, Li Y^#, Xia W, Reddig K, Hu W, Xie W, Li HS*, Han J* (2011). A Drosophila metallophosphoesterase mediates deglycosylation of rhodopsin. EMBO J 30: 3701-13.

21.   Han J^#, Reddig K and Li HS* (2007). Prolonged Gq activity triggers fly rhodopsin endocytosis and degradation and reduces photoreceptor sensitivity. EMBO J 26:4966-73.

22.   Han J^#, Gong P^#, Reddig K^#, Mitra M, Guo P and Li HS* (2006). The fly CAMTA transcription factor potentiates deactivation of the G protein-coupled light receptor rhodopsin. Cell 127: 847-858.